Partial Versus Complete Bacillus Calmette-Guerin Intravesical Therapy and Bladder Cancer Outcomes in High-risk Non-muscle-invasive Bladder Cancer: Is NIMBUS the Full Story?

ABSTRACT:

Background

It is important to understand the implications of reduced bacillus Calmette-Guérin (BCG) treatment intensity, given global shortages and early termination of the NIMBUS trial.

Objective

To assess the association of partial versus complete BCG induction with outcomes.

Design setting and participants

This is a retrospective cohort study of veterans diagnosed with high-risk non-muscle-invasive bladder cancer (NMIBC; high grade [HG] Ta, T1, or carcinoma in situ) between 2005 and 2011 with follow-up through 2014.

Intervention

Patients were categorized into partial versus complete BCG induction (one to five vs five or more instillations). Partial BCG induction subgroups were defined for comparison with the NIMBUS trial.

Outcome measurements and statisti

SUBMITTER: Rezaee ME 

PROVIDER: S-EPMC8317819 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature