Single-lesion Prostate-specific Membrane Antigen Protein Expression (PSMA) and Response to [¹⁷⁷Lu]-PSMA-ligand Therapy in Patients with Castration-resistant Prostate Cancer.

ABSTRACT: Initial reports of a clinical response in patients treated with the radioligand [¹⁷⁷Lu]-PSMA-617 for castration-resistant prostate cancer (CRPC) are promising, despite known inter- and intrapatient heterogeneity. In metastatic CRPC, we examined the association of baseline immunohistochemical (IHC) expression of prostate-specific membrane antigen (PSMA) in a single lesion and responsiveness to [¹⁷⁷Lu]-PSMA-617 therapy, measured as the PSMA maximum standardized uptake value (SUV_max). Between 2015 and 2020, 19 patients with multiple metastases underwent single-lesion biopsy, [⁶⁸Ga]-PSMA positron emission tomography (PET) imaging, and treatment with [¹⁷⁷Lu]-PSMA-617. A monoclonal anti-PSMA antibody was used to semiquantitatively assess PSM

SUBMITTER: Stangl-Kremser J 

PROVIDER: S-EPMC8317820 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature