CDH12 as a Candidate Gene for Kidney Injury in Posterior Urethral Valve Cases: A Genome-wide Association Study Among Patients with Obstructive Uropathies.

ABSTRACT:

Background

Posterior urethral valves (PUVs) and ureteropelvic junction obstruction (UPJO) are congenital obstructive uropathies that may impair kidney development.

Objective

To identify genetic variants associated with kidney injury in patients with obstructive uropathy.

Design setting and participants

We included 487 patients born in 1981 or later who underwent pyeloplasty or valve resection before 18 yr of age in the discovery phase, 102 PUV patients in a first replication phase, and 102 in a second replication phase.

Outcome measurements and statistical analysis

Signs of kidney injury were defined as dialysis, nephrectomy, kidney transplantation, estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m², high blood pressure, antihypertensive

SUBMITTER: van der Zanden LFM 

PROVIDER: S-EPMC8317879 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature