Transplantation of an obesity-associated human gut microbiota to mice induces vascular dysfunction and glucose intolerance.

ABSTRACT: Recent preclinical data suggest that alterations in the gut microbiota may be an important factor linking obesity to vascular dysfunction, an early sign of cardiovascular disease. The purpose of this study was to begin translation of these preclinical data by examining whether vascular phenotypes in humans are transmissible through the gut microbiota. We hypothesized that germ-free mice colonized with gut microbiota from obese individuals would display diminished vascular function compared to germ-free mice receiving microbiota from lean individuals.We transplanted fecal material from obese and lean age-and sex-matched participants with disparate vascular function to germ-free mice. Using Principle Component Analysis, the microbiota of colonized mice separated by donor group along the firs

SUBMITTER: Trikha SRJ 

PROVIDER: S-EPMC8317959 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature