Enhanced Detection of Mycobacterium bovis-Specific T Cells in Experimentally-Infected Cattle.

ABSTRACT: Bovine tuberculosis (bTB), caused by infection with Mycobacterium bovis, continues to be a major economic burden associated with production losses and a public health concern due to its zoonotic nature. As with other intracellular pathogens, cell-mediated immunity plays an important role in the control of infection. Characterization of such responses is important for understanding the immune status of the host, and to identify mechanisms of protective immunity or immunopathology. This type of information can be important in the development of vaccination strategies, diagnostic assays, and in predicting protection or disease progression. However, the frequency of circulating M. bovis-specific T cells are often low, making the analysis of such responses difficult. As previously

SUBMITTER: Boggiatto PM 

PROVIDER: S-EPMC8317970 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature