An electrodiffusive neuron-extracellular-glia model for exploring the genesis of slow potentials in the brain.

ABSTRACT: Within the computational neuroscience community, there has been a focus on simulating the electrical activity of neurons, while other components of brain tissue, such as glia cells and the extracellular space, are often neglected. Standard models of extracellular potentials are based on a combination of multicompartmental models describing neural electrodynamics and volume conductor theory. Such models cannot be used to simulate the slow components of extracellular potentials, which depend on ion concentration dynamics, and the effect that this has on extracellular diffusion potentials and glial buffering currents. We here present the electrodiffusive neuron-extracellular-glia (edNEG) model, which we believe is the first model to combine compartmental neuron modeling with an electrodiffusi

SUBMITTER: Sætra MJ 

PROVIDER: S-EPMC8318289 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature