Testosterone and socioeconomic position: Mendelian randomization in 306,248 men and women in UK Biobank.

ABSTRACT: Men with more advantaged socioeconomic position (SEP) have been observed to have higher levels of testosterone. It is unclear whether these associations arise because testosterone has a causal impact on SEP. In 306,248 participants of UK Biobank, we performed sex-stratified genome-wide association analysis to identify genetic variants associated with testosterone. Using the identified variants, we performed Mendelian randomization analysis of the influence of testosterone on socioeconomic position, including income, employment status, neighborhood-level deprivation, and educational qualifications; on health, including self-rated health and body mass index; and on risk-taking behavior. We found little evidence that testosterone affected socioeconomic position, health, or risk-taking. Our re

SUBMITTER: Harrison S 

PROVIDER: S-EPMC8318368 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature