Visceral adiposity, muscle composition, and exercise tolerance in heart failure with preserved ejection fraction.

ABSTRACT:

Aims

Visceral adipose tissue (AT) promotes inflammation and may be associated with disease progression in heart failure with preserved ejection fraction (HFpEF). We characterized regional AT distribution in HFpEF patients and controls and analysed associations with co-morbidities and exercise tolerance.

Methods and results

Magnetic resonance imaging was performed to quantify epicardial, liver, abdominal, and thigh skeletal muscle AT. We assessed New York Heart Association (NYHA) class, 6 min walk distance, and global well-being score. Multivariable linear regression models adjusting for body surface area were used. We studied 55 HFpEF patients (41 women, mean age 67 ± 11 years) and 33 controls (21 women, mean age 57 ± 10 years). Epicardial AT (median [interquartile range] 4.

SUBMITTER: Ying W 

PROVIDER: S-EPMC8318398 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature