Does renin-angiotensin system inhibition have impacts on muscle mass and bone mineral density in heart failure patients?

ABSTRACT:

Aims

Results of experimental studies have indicated the possibility of muscle and bone mass being negatively regulated by renin-angiotensin system (RAS) activation, but that possibility has not been analysed in patients with heart failure (HF).

Methods and results

Data for HF patients who received a dual-energy X-ray absorptiometry scan in our hospital were reviewed. Propensity scores for the use of RAS inhibitors (RASIs) were calculated using a multivariate logistic regression model to minimize selection bias. One hundred sixty pairs of patients were extracted. Plasma aldosterone concentration was significantly lower in the RASIs group than in the no-RASIs group (119 [IQR 71-185] vs. 94 [IQR 60-131] pg/mL, P = 0.003), confirming RAS inhibition in the RASIs group. Skeletal m

SUBMITTER: Katano S 

PROVIDER: S-EPMC8318416 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature