Right-ventricular dysfunction in HFpEF is linked to altered cardiomyocyte Ca²⁺ homeostasis and myofilament sensitivity.

ABSTRACT:

Aims

Heart failure with preserved ejection fraction (HFpEF) is frequently (30%) associated with right ventricular (RV) dysfunction, which increases morbidity and mortality in these patients. Yet cellular mechanisms of RV remodelling and RV dysfunction in HFpEF are not well understood. Here, we evaluated RV cardiomyocyte function in a rat model of metabolically induced HFpEF.

Methods and results

Heart failure with preserved ejection fraction-prone animals (ZSF-1 obese) and control rats (Wistar Kyoto) were fed a high-caloric diet for 13 weeks. Haemodynamic characterization by echocardiography and invasive catheterization was performed at 22 and 23 weeks of age, respectively. After sacrifice, organ morphometry, RV histology, isolated RV cardiomyocyte function, and calcium (Ca

SUBMITTER: Hegemann N 

PROVIDER: S-EPMC8318431 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature