Serum creatinine and cystatin C-based estimates of glomerular filtration rate are misleading in acute heart failure.

ABSTRACT:

Aims

We aimed to test whether the endogenous filtration markers serum creatinine or cystatin C and equation-based estimates of glomerular filtration rate (GFR) based on these markers appropriately reflect changes of measured GFR in patients with acute heart failure.

Methods

In this prospective cohort study of 50 hospitalized acute heart failure patients undergoing decongestive therapy, we applied an intravenous visible fluorescent injectate (VFI), consisting of a low molecular weight component to measure GFR and a high molecular weight component to correct for measured plasma volume. Thirty-eight patients had two sequential GFR measurements 48 h apart. The co-primary endpoints of the study were safety of VFI and plasma stability of the high molecular weight component. A key

SUBMITTER: Swolinsky JS 

PROVIDER: S-EPMC8318462 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature