Effects of echo-optimization of left ventricular assist devices on functional capacity, a randomized controlled trial.

ABSTRACT:

Aims

After the implantation of a left ventricular assist device (LVAD), many patients continue to experience exercise intolerance. VAFRACT trial evaluates the additional benefit of LVAD echo-guided optimization (EO) on functional capacity (FC), measured by cardiopulmonary exercise test (CPET), and quality of life (QoL).

Methods and results

Twenty-seven patients were randomized in a 1:1 ratio to EO (EO group) vs. standard settings (CONTROL group) at least after 3 months from LVAD implant procedure. The optimal device speed was defined as the one that allows an intermittent aortic valve opening and a neutral position of the interventricular septum without increasing aortic or tricuspid regurgitation and preserving right ventricular function. The primary endpoint was peak oxyge

SUBMITTER: Lilliu M 

PROVIDER: S-EPMC8318497 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature