Clinical phenogroups are more effective than left ventricular ejection fraction categories in stratifying heart failure outcomes.

ABSTRACT:

Aims

Heart failure (HF) guidelines place patients into 3 discrete groups according to left ventricular ejection fraction (LVEF): reduced (<40%), mid-range (40-49%), and preserved LVEF (≥50%). We assessed whether clinical phenogroups offer better prognostication than LVEF.

Methods and results

This was a sub-study of the Patient-Centered Care Transitions in HF trial. We analysed baseline characteristics of hospitalized patients in whom LVEF was recorded. We used unsupervised machine learning to identify clinical phenogroups and, thereafter, determined associations between phenogroups and outcomes. Primary outcome was the composite of all-cause death or rehospitalization at 6 and 12 months. Secondary outcome was the composite cardiovascular death or HF rehospitalization at 6 an

SUBMITTER: Gevaert AB 

PROVIDER: S-EPMC8318507 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature