Toxic elements in follicular fluid adversely influence the likelihood of pregnancy and live birth in women undergoing IVF.

ABSTRACT:

Study question

Are follicular fluid (FF), arsenic (As), mercury (Hg), cadmium (Cd) and lead (Pb) concentrations associated with IVF outcomes among women undergoing IVF?

Summary answer

There was a non-linear association between higher FF Hg concentration and a lower likelihood of biochemical pregnancy and live birth. Higher FF Pb concentration was also associated with a lower probability of live birth.

What is known already

Previous research suggests that toxic elements may affect fertility among couples conceiving with and without assistance. However, the results have been inconsistent, possibly related in part to exposure misclassification. Very few studies have used ovarian FF to measure toxic elements, as it requires an invasive collection procedure, yet it may off

SUBMITTER: Butts CD 

PROVIDER: S-EPMC8318822 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature