Bone marrow adiposity inversely correlates with bone turnover in pediatric renal osteodystrophy.

ABSTRACT: Bone marrow adiposity is associated with bone disease in the general population. Although chronic kidney disease (CKD) is associated with increased bone fragility, the correlation between marrow adiposity and bone health in CKD is unknown. We evaluated the relationship between bone marrow adipocytes and bone histomorphometry in 32 pediatric patients. We also evaluated the effects of growth hormone and calcitriol (1,25(OH)₂D₃)-two therapies commonly prescribed for pediatric bone disease-on marrow adiposity and bone histomorphometry. Finally, the adipogenic potential of primary human osteoblasts from CKD patients was assessed in vitro, both alone and in the presence of 1,25(OH)₂D₃. In cross-sectional analysis, marrow adipocyte number per tis

SUBMITTER: Sirimongkolchaiyakul O 

PROVIDER: S-EPMC8318854 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature