Re-appraisal of the obesity paradox in heart failure: a meta-analysis of individual data.

ABSTRACT:

Background

Higher body mass index (BMI) is associated with better outcome compared with normal weight in patients with HF and other chronic diseases. It remains uncertain whether the apparent protective role of obesity relates to the absence of comorbidities. Therefore, we investigated the effect of BMI on outcome in younger patients without co-morbidities as compared to older patients with co-morbidities in a large heart failure (HF) population.

Methods

In an individual patient data analysis from pooled cohorts, 5,819 patients with chronic HF and data available on BMI, co-morbidities and outcome were analysed. Patients were divided into four groups based on BMI (i.e. ≤ 18.5 kg/m², 18.5-25.0 kg/m²; 25.0-30.0 kg/m²; 30.0 kg/m²). Pri

SUBMITTER: Marcks N 

PROVIDER: S-EPMC8318940 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature