Developing and validating models to predict sudden death and pump failure death in patients with heart failure and preserved ejection fraction.

ABSTRACT:

Background

Sudden death (SD) and pump failure death (PFD) are leading modes of death in heart failure and preserved ejection fraction (HFpEF). Risk stratification for mode-specific death may aid in patient enrichment for new device trials in HFpEF.

Methods

Models were derived in 4116 patients in the Irbesartan in Heart Failure with Preserved Ejection Fraction trial (I-Preserve), using competing risks regression analysis. A series of models were built in a stepwise manner, and were validated in the Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity (CHARM)-Preserved and Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT) trials.

Results

The clinical model for SD included older age, men, lower LVEF,

SUBMITTER: Shen L 

PROVIDER: S-EPMC8318942 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature