Intravenous iron for heart failure with evidence of iron deficiency: a meta-analysis of randomised trials.

ABSTRACT:

Background

The recent AFFIRM-AHF trial assessing the effect of intravenous (IV) iron on outcomes in patients hospitalised with worsening heart failure who had iron deficiency (ID) narrowly missed its primary efficacy endpoint of recurrent hospitalisations for heart failure (HHF) or cardiovascular (CV) death. We conducted a meta-analysis to determine whether these results were consistent with previous trials.

Methods

We searched for randomised trials of patients with heart failure investigating the effect of IV iron vs placebo/control groups that reported HHF and CV mortality from 1st January 2000 to 5th December 2020. Seven trials were identified and included in this analysis. A fixed effect model was applied to assess the effects of IV iron on the composite of first HHF or

SUBMITTER: Graham FJ 

PROVIDER: S-EPMC8318946 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature