β2M Signals Monocytes Through Non-Canonical TGFβ Receptor Signal Transduction.

ABSTRACT:

Rationale

Circulating monocytes can have proinflammatory or proreparative phenotypes. The endogenous signaling molecules and pathways that regulate monocyte polarization in vivo are poorly understood. We have shown that platelet-derived β2M (β-2 microglobulin) and TGF-β (transforming growth factor β) have opposing effects on monocytes by inducing inflammatory and reparative phenotypes, respectively, but each bind and signal through the same receptor. We now define the signaling pathways involved.

Objective

To determine the molecular mechanisms and signal transduction pathways by which β2M and TGF-β regulate monocyte responses both in vitro and in vivo.

Methods and results

Wild-type- (WT) and platelet-specific β2M knockout mice were treated intravenously with either β2

SUBMITTER: Hilt ZT 

PROVIDER: S-EPMC8319031 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature