New Insights Into Understanding Rotor Versus Focal Activation in Patients With Persistent Atrial Fibrillation.

ABSTRACT:

Objectives

This study was to test the hypotheses that: 1) when using phase analysis, repetitive Wannabe re-entry produces a phase singularity point (i.e., a rotor); and 2) the location of the stable rotor is close to the focal source.

Background

Recent contact mapping studies in patients with persistent atrial fibrillation (AF) demonstrated that phase analysis produced a different mechanistic result than classical activation sequence analysis. Our studies in patients with persistent AF showed that focal sources sometimes produced repetitive Wannabe re-entry, that is, incomplete re-entry.

Methods

During open heart surgery, we recorded activation from both atria simultaneously using 510 to 512 electrodes in 12 patients with persistent AF. We performed activation sequenc

SUBMITTER: Lee S 

PROVIDER: S-EPMC8319037 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature