High ethanol preference and dissociated memory are co-occurring phenotypes associated with hippocampal GABA_AR-δ receptor levels.

ABSTRACT: Alcohol use disorder (AUD) frequently co-occurs with dissociative disorders and disorders with dissociative symptoms, suggesting a common neurobiological basis. It has been proposed that facilitated information processing under the influence of alcohol, resulting in the formation of dissociated memories, might be an important factor controlling alcohol use. Access to such memories is facilitated under the effect of alcohol, thus further reinforcing alcohol use. To interrogate possible mechanisms associated with these phenotypes, we used a mouse model of dissociative amnesia, combined with a high-alcohol preferring (HAP) model of AUD. Dissociated memory was induced by activation of hippocampal extrasynaptic GABA type A receptor delta subunits (GABA_AR-δ), which control tonic inhib

SUBMITTER: Jovasevic V 

PROVIDER: S-EPMC8319099 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature