Microglia react to partner loss in a sex- and brain site-specific manner in prairie voles.

ABSTRACT: Positive social relationships are paramount for the survival of mammals and beneficial for mental and physical health, buffer against stressors, and even promote appropriate immune system functioning. By contrast, impaired social relationships, social isolation, or the loss of a bonded partner lead to aggravated physical and mental health. For example, in humans partner loss is detrimental for the functioning of the immune system and heightens the susceptibility for the development of post-traumatic stress disorders, anxiety disorders, and major depressive disorders. To understand potential underlying mechanisms, the monogamous prairie vole can provide important insights. In the present study, we separated pair bonded male and female prairie voles after five days of co-housing, subjected t

SUBMITTER: Pohl TT 

PROVIDER: S-EPMC8319132 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature