[¹⁸F]NaF PET-MRI provides direct in-vivo evidence of the association between bone metabolic activity and adjacent synovitis in knee osteoarthritis: a cross-sectional study.

ABSTRACT:

Objective

Synovitis is hypothesized to play a role in the development and growth of osteophytes. Our objectives were to use hybrid positron emission tomography-magnetic resonance imaging (PET-MRI) to (1) determine whether synovitis adjacent to peripheral bone subregions with increased metabolic activity is greater than adjacent to regions without increased metabolic activity and (2) assess the association between subregional bone metabolic activity and adjacent synovitis.

Design

We recruited 11 participants (22 knees) with a diagnosis of OA in at least one knee. Simultaneous bilateral knee PET-MRI was performed. We quantified bone metabolic activity using the radiotracer [¹⁸F]sodium fluoride ([¹⁸F]NaF) with calculation of maximum standardized uptake val

SUBMITTER: MacKay JW 

PROVIDER: S-EPMC8319134 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature