CoFe₂O₄-Quantum Dots for Synergistic Photothermal/Photodynamic Therapy of Non-small-Cell Lung Cancer Via Triggering Apoptosis by Regulating PI3K/AKT Pathway.

ABSTRACT: Non-small-cell lung cancer (NSCLC) has become the second most diagnosed malignant tumors worldwide. As our long-term interests in seeking nanomaterials to develop strategies of cancer therapies, we herein constructed novel CoFe₂O₄-quantum dots (QDs) with outstanding synergistic photothermal/photodynamic property which suppressed NSCLC efficiently without apparent toxicity. We showed that the combination of CoFe₂O₄-QDs + NIR treatment induces apoptosis of NSCLC cells. In addition, the CoFe₂O₄-QDs + NIR treatment also promotes reactive oxygen species generation to trigger cell death through regulating PI3K/AKT pathway. Moreover, the CoFe₂O₄-QDs + NIR treatment successfully eliminates tumor xenografts in v

SUBMITTER: Liu J 

PROVIDER: S-EPMC8319264 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature