Ontology highlight
ABSTRACT:
SUBMITTER: Shankar TS
PROVIDER: S-EPMC8319341 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Shankar Thirupura S TS Ramadurai Dinesh K A DKA Steinhorst Kira K Sommakia Salah S Badolia Rachit R Thodou Krokidi Aspasia A Calder Dallen D Navankasattusas Sutip S Sander Paulina P Kwon Oh Sung OS Aravamudhan Aishwarya A Ling Jing J Dendorfer Andreas A Xie Changmin C Kwon Ohyun O Cheng Emily H Y EHY Whitehead Kevin J KJ Gudermann Thomas T Richardson Russel S RS Sachse Frank B FB Schredelseker Johann J Spitzer Kenneth W KW Chaudhuri Dipayan D Drakos Stavros G SG
Nature communications 20210728 1
Voltage dependent anion channel 2 (VDAC2) is an outer mitochondrial membrane porin known to play a significant role in apoptosis and calcium signaling. Abnormalities in calcium homeostasis often leads to electrical and contractile dysfunction and can cause dilated cardiomyopathy and heart failure. However, the specific role of VDAC2 in intracellular calcium dynamics and cardiac function is not well understood. To elucidate the role of VDAC2 in calcium homeostasis, we generated a cardiac ventricu ...[more]