Performance assessment of a multi-epitope chimeric antigen for the serological diagnosis of acute Mayaro fever.

ABSTRACT: Mayaro virus (MAYV), which causes mayaro fever, is endemic to limited regions of South America that may expand due to the possible involvement of Aedes spp. mosquitoes in its transmission. Its effective control will require the accurate identification of infected individuals, which has been restricted to nucleic acid-based tests due to similarities with other emerging members of the Alphavirus genus of the Togaviridae family; both in structure and clinical symptoms. Serological tests have a more significant potential to expand testing at a reasonable cost, and their performance primarily reflects that of the antigen utilized to capture pathogen-specific antibodies. Here, we describe the assembly of a synthetic gene encoding multiple copies of antigenic determinants mapped from the nsP1, ns

SUBMITTER: Napoleao-Pego P 

PROVIDER: S-EPMC8319364 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature