Memory, processing of emotional stimuli, and volume of limbic structures in pediatric-onset multiple sclerosis.

ABSTRACT:

Objective

The limbic system is involved in memory and in processing of emotional stimuli. We measured volume of the hippocampus, amygdala, and thalamus, and assessed their relative contribution to episodic memory and emotion identification in POMS.

Method

Sixty-five POMS participants (M_age = 18.3 ± 3.9 years; 48 female (73.8%)), average disease duration = 3.8 ± 3.8 years) and 76 age- and sex-matched controls (M_age = 18.1 ± 4.6 years; 49 female (64.5%)) completed the Penn Computerized Neurocognitive Battery (PCNB); 59 of 65 POMS participants and 69 out of 76 controls underwent 3 T MRI scanning. We derived age-adjusted Z-scores on accuracy and response time (RT) measures of episodic memory and emotion identification of the PCNB. Magnetic resonance imaging

SUBMITTER: Fabri TL 

PROVIDER: S-EPMC8319518 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature