Prognostic Value of Regression Rate of Plasma EBV DNA After Induction Chemotherapy for Stage II-IVA Nasopharyngeal Carcinoma.

ABSTRACT:

Background/objective

We aimed to explore the prognostic value of regression rate (RR) of plasma Epstein-Barr virus (EBV) DNA after induction chemotherapy (IC) in patients with stages II-IVA nasopharyngeal carcinoma (NPC).

Methods

Eligible patients receiving IC followed by concurrent chemoradiotherapy were included. The cut-off value of pre-treatment EBV DNA (pre-IC DNA) and RR were identified by receiver operating curve (ROC). Recursive partitioning analysis (RPA) was applied to create new staging. Harrell's c-index and time-independent ROC were employed to compare different RPA staging.

Results

In total, 1,184 patients were included. The cut-off values of pre-IC DNA and RR were 16,200 copies/ml and 95.127% for patients receiving two cycles, and 5,520 copies/ml and 99

SUBMITTER: Peng H 

PROVIDER: S-EPMC8319726 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature