Development and validation of a score to predict mortality in ICU patients with sepsis: a multicenter retrospective study.

ABSTRACT:

Background

Early and accurate identification of septic patients at high risk for ICU mortality can help clinicians make optimal clinical decisions and improve the patients' outcomes. This study aimed to develop and validate (internally and externally) a mortality prediction score for sepsis following admission in the ICU.

Methods

We extracted data retrospectively regarding adult septic patients from one teaching hospital in Wenzhou, China and a large multi-center critical care database from the USA. Demographic data, vital signs, laboratory values, comorbidities, and clinical outcomes were collected. The primary outcome was ICU mortality. Through multivariable logistic regression, a mortality prediction score for sepsis was developed and validated.

Results

Four thousa

SUBMITTER: Weng J 

PROVIDER: S-EPMC8319895 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature