Absence of Desmin Results in Impaired Adaptive Response to Mechanical Overloading of Skeletal Muscle.

ABSTRACT: Background: Desmin is a muscle-specific protein belonging to the intermediate filament family. Desmin mutations are linked to skeletal muscle defects, including inherited myopathies with severe clinical manifestations. The aim of this study was to examine the role of desmin in skeletal muscle remodeling and performance gain induced by muscle mechanical overloading which mimics resistance training. Methods: Plantaris muscles were overloaded by surgical ablation of gastrocnemius and soleus muscles. The functional response of plantaris muscle to mechanical overloading in desmin-deficient mice (DesKO, n = 32) was compared to that of control mice (n = 36) after 7-days or 1-month overloading. To elucidate the molecular mechanisms implicated in the observed part

SUBMITTER: Joanne P 

PROVIDER: S-EPMC8320001 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature