Persistent deficiency of mucosa-associated invariant T (MAIT) cells during alcohol-related liver disease.

ABSTRACT:

Background

Alcohol-related liver disease (ALD) is a major cause of chronic liver diseases. Inflammatory response is a basic pathological feature of ALD. Mucosal-associated invariant T(MAIT) cells are a novel population of innate immune cells, which may be depleted in various inflammatory diseases. However, the changes of MAIT cell in ALD remains unclear.

Results

In this study, the levels of MAIT cell were significantly decreased in patients with alcoholic fatty liver disease, alcoholic cirrhosis, and mixed cirrhosis (alcoholic + viral). Furthermore, the reduction of circulating MAIT cells was correlated with liver function in patients with cirrhosis. Functional changes among circulating MAIT cells in patients with alcoholic cirrhosis, including increased production of IL-17A

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC8320031 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature