Performance of Prostate Health Index in Biopsy Naive Black Men.

ABSTRACT:

Purpose

The Prostate Health Index is validated for prostate cancer detection but has not been well validated for Gleason grade group 2-5 prostate cancer detection in Black men. We hypothesize that the Prostate Health Index has greater accuracy than prostate specific antigen for detection of Gleason grade group 2-5 prostate cancer. We estimated probability of overall and Gleason grade group 2-5 prostate cancer across previously established Prostate Health Index ranges and identified Prostate Health Index cutoffs that maximize specificity for Gleason grade group 2-5 prostate cancer with sensitivity >90%.

Materials and methods

We recruited a "cancer-free" Black control cohort (135 patients) and a cohort of biopsy naïve Black men (158) biopsied for elevated prostate specific ant

SUBMITTER: Babajide R 

PROVIDER: S-EPMC8320068 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature