Oral Misoprostol alone versus oral misoprostol followed by oxytocin for labour induction in women with hypertension in pregnancy (MOLI): protocol for a randomised controlled trial.

ABSTRACT:

Background

Every year approximately 30,000 women die from hypertensive disease in pregnancy. Magnesium sulphate and anti-hypertensives reduce morbidity, but delivery is the only cure. Low dose oral misoprostol, a prostaglandin E1 analogue, is a highly effective method for labour induction. Usually, once active labour has commenced, the misoprostol is replaced with an intravenous oxytocin infusion if ongoing stimulation is required. However, some studies have shown that oral misoprostol can be continued into active labour, a simpler and potentially more acceptable protocol for women. To date, these two protocols have never been directly compared.

Methods

This pragmatic, open-label, randomised trial will compare a misoprostol alone labour induction protocol with the standard m

SUBMITTER: Bracken H 

PROVIDER: S-EPMC8320158 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature