Association between NR3C1 gene polymorphisms and age-related hearing impairment in Qingdao Chinese elderly.

ABSTRACT:

Background

Age-related hearing impairment (ARHI) has attracted increasing attention recently. It is caused by genetic and environmental factors. A number of ARHI-related genes have been found. This study aimed to detect the potential association between NR3C1 gene polymorphisms and ARHI by means of weighted allele score.

Methods

A total of 861 participants from Qingdao city were selected by means of cluster random sampling. We statistically evaluated the characteristics of individuals and used the Mann-Whitney U test or chi-square test for comparison. The publicly available expression quantitative trait locus (eQTL) was queried on the website of the Genotype-Tissue Expression (GTEx). We used the weighted allele score and logistic regression analysis to explore the associatio

SUBMITTER: Song W 

PROVIDER: S-EPMC8320226 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature