Adiponectin to leptin ratio reflects inflammatory burden and survival in COVID-19.

ABSTRACT:

Aim

Obesity is a risk factor for COVID-19, but the underlying mechanisms are unclear. We investigated the role of adiponectin (an anti-inflammatory adipokine), leptin (a pro-inflammatory adipokine) and their ratio (Adpn/Lep) in this context.

Design

Single-centre, prospective observational study.

Methods

Adiponectin and leptin were measured in 60 COVID-19 patients with mild (not hospitalised, n=11), moderate (hospitalised but not requiring intensive care, n=25) and severe (admission to the intensive care unit [ICU] or death, n=24) disease.

Results

Adiponectin and leptin levels were similar across severity groups, but patients with moderate severity had the highest Adpn/Lep ratio (1.2 [0.5; 2.0], 5.0 [1.6; 11.2], 2.1 [1.0; 3.6] in mild, moderate and severe diseas

SUBMITTER: Di Filippo L 

PROVIDER: S-EPMC8320244 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature