Association of Protective HLA-A With HLA-B^∗27 Positive Ankylosing Spondylitis.

ABSTRACT:

Objectives

To further elucidate the role of the MHC in ankylosing spondylitis by typing 17 genes, searching for HLA-B^∗27 independent associations and assessing the impact of sex on this male biased disease.

Methods

High-confidence two-field resolution genotyping was performed on 310 cases and 2196 controls using an n-1 concordance method. Protein-coding variants were called from next-generation sequencing reads using up to four software programs and the consensus result recorded. Logistic regression tests were applied to the dataset as a whole, and also in stratified sets based on sex or HLA-B^∗27 status. The amino acids driving association were also examined.

Results

Twenty-five HLA protein-coding variants were signifi

SUBMITTER: Nordin J 

PROVIDER: S-EPMC8320510 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature