Brief Report: Vascular Dysfunction and Monocyte Activation Among Women With HIV.

ABSTRACT:

Objective

Women with HIV (WHIV) on antiretroviral therapy (ART) face an increased risk of cardiovascular disease (CVD) in the context of heightened systemic immune activation. Aortic stiffness, a measure of vascular dysfunction and a robust predictor of CVD outcomes, is highly influenced by immune activation. We compared aortic stiffness among women with and without HIV and examined interrelationships between aortic stiffness and key indices of systemic immune activation.

Methods

Twenty WHIV on ART and 14 women without HIV group-matched on age and body mass index (BMI) were prospectively recruited and underwent cardiovascular magnetic resonance imaging, as well as metabolic and immune phenotyping.

Results

Age and BMI did not differ significantly across groups (age: 52

SUBMITTER: Toribio M 

PROVIDER: S-EPMC8320532 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature