Biosynthetic Cyclization Catalysts for the Assembly of Peptide and Polyketide Natural Products.

ABSTRACT: Many biologically active natural products are synthesized by nonribosomal peptide synthetases (NRPSs), polyketide synthases (PKSs) and their hybrids. These megasynthetases contain modules possessing distinct catalytic domains that allow for substrate initiation, chain extension, processing and termination. At the end of a module, a terminal domain, usually a thioesterase (TE), is responsible for catalyzing the release of the NRPS or PKS as a linear or cyclized product. In this review, we address the general cyclization mechanism of the TE domain, including oligomerization and the fungal C-C bond forming Claisen-like cyclases (CLCs). Additionally, we include examples of cyclization catalysts acting within or at the end of a module. Furthermore, condensation-like (C_T) domains, ter

SUBMITTER: Adrover-Castellano ML 

PROVIDER: S-EPMC8320681 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature