Dynamic polyhedral actomyosin lattices remodel micron-scale curved membranes during exocytosis in live mice.

ABSTRACT: Actomyosin networks, the cell's major force production machineries, remodel cellular membranes during myriad dynamic processes^1,2 by assembling into various architectures with distinct force generation properties^3,4. While linear and branched actomyosin architectures are well characterized in cell-culture and cell-free systems³, it is not known how actin and myosin networks form and function to remodel membranes in complex three-dimensional mammalian tissues. Here, we use four-dimensional spinning-disc confocal microscopy with image deconvolution to acquire macromolecular-scale detail of dynamic actomyosin networks in exocrine glands of live mice. We address how actin and myosin organize around large membrane-bound secretory vesicles and generate the forces

SUBMITTER: Ebrahim S 

PROVIDER: S-EPMC8320706 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature