Inhibitory Molecules PD-1, CD73 and CD39 Are Expressed by CD8⁺ T Cells in a Tissue-Dependent Manner and Can Inhibit T Cell Responses to Stimulation.

ABSTRACT: The salivary gland is an important tissue for persistence and transmission of multiple viruses. Previous work showed that salivary gland tissue-resident CD8⁺ T cells elicited by viruses were poorly functional ex vivo. Using a model of persistent murine cytomegalovirus (MCMV) infection, we now show that CD8⁺ T cells in the salivary gland and other non-lymphoid tissues of mice express multiple molecules associated with T cell exhaustion including PD-1, CD73 and CD39. Strikingly however, these molecules were expressed independently of virus or antigen. Rather, PD-1-expressing T cells remained PD-1⁺ after migration into tissues regardless of infection, while CD73 was activated on CD8⁺ T cells by TGF-β signaling. Blockade of PD-L1, but not CD73

SUBMITTER: Smith CJ 

PROVIDER: S-EPMC8320728 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature