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RNA diversification by a self-reproducing ribozyme revealed by deep sequencing and kinetic modelling.

ABSTRACT: We demonstrate that a recombinase ribozyme achieves multiple functions in the same reaction network: self-reproduction, iterative elongation and circularization of other RNAs, leading to synthesis of diverse products predicted by a kinetic model. This shows that key mechanisms can be integrated and controlled toward Darwinian evolution in RNA reaction networks.

SUBMITTER: Jeancolas C 

PROVIDER: S-EPMC8320737 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature

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RNA diversification by a self-reproducing ribozyme revealed by deep sequencing and kinetic modelling.

Jeancolas Cyrille C   Matsubara Yoshiya J YJ   Vybornyi Mykhailo M   Lambert Camille N CN   Blokhuis Alex A   Alline Thomas T   Griffiths Andrew D AD   Ameta Sandeep S   Krishna Sandeep S   Nghe Philippe P  

Chemical communications (Cambridge, England) 20210701 61

We demonstrate that a recombinase ribozyme achieves multiple functions in the same reaction network: self-reproduction, iterative elongation and circularization of other RNAs, leading to synthesis of diverse products predicted by a kinetic model. This shows that key mechanisms can be integrated and controlled toward Darwinian evolution in RNA reaction networks. ...[more]

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