RNA diversification by a self-reproducing ribozyme revealed by deep sequencing and kinetic modelling.
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ABSTRACT:
SUBMITTER: Jeancolas C
PROVIDER: S-EPMC8320737 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Publications
RNA diversification by a self-reproducing ribozyme revealed by deep sequencing and kinetic modelling.
Jeancolas Cyrille C Matsubara Yoshiya J YJ Vybornyi Mykhailo M Lambert Camille N CN Blokhuis Alex A Alline Thomas T Griffiths Andrew D AD Ameta Sandeep S Krishna Sandeep S Nghe Philippe P
Chemical communications (Cambridge, England) 20210701 61
We demonstrate that a recombinase ribozyme achieves multiple functions in the same reaction network: self-reproduction, iterative elongation and circularization of other RNAs, leading to synthesis of diverse products predicted by a kinetic model. This shows that key mechanisms can be integrated and controlled toward Darwinian evolution in RNA reaction networks. ...[more]
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