Mapping Autoantibodies in Children With Acute Rheumatic Fever.

ABSTRACT:

Background

Acute rheumatic fever (ARF) is a serious sequela of Group A Streptococcus (GAS) infection associated with significant global mortality. Pathogenesis remains poorly understood, with the current prevailing hypothesis based on molecular mimicry and the notion that antibodies generated in response to GAS infection cross-react with cardiac proteins such as myosin. Contemporary investigations of the broader autoantibody response in ARF are needed to both inform pathogenesis models and identify new biomarkers for the disease.

Methods

This study has utilised a multi-platform approach to profile circulating autoantibodies in ARF. Sera from patients with ARF, matched healthy controls and patients with uncomplicated GAS pharyngitis were initially analysed for autoreac

SUBMITTER: McGregor R 

PROVIDER: S-EPMC8320770 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature