Facile Synthesis of a Pt(IV) Prodrug of Cisplatin and Its Intrinsically ^195mPt Labeled Analog: A Step Closer to Cancer Theranostic.

ABSTRACT:

Background aims and objectives

Cisplatin is extensively used in chemotherapy for treatment of a broad range of cancers. But its undesired side reactions with biomolecules that lead to severe side effects especially on kidney and nervous system, are limiting its clinical utility. To reduce its side effects, the kinetically inert Pt(IV) prodrug was recognized as an alternative approach from satisfactory results of preliminary experiments. But, its approval as anticancer drug for clinical use requires detailed investigations of its anticancer action and pharmacological pathways by employing its analogue which can be traced by a suitable technique. As a step closer towards translation of Pt(IV)-based prodrug from research to clinical level, a protocol for efficient synthesis of ¹⁹

SUBMITTER: Sharma KS 

PROVIDER: S-EPMC8320819 | biostudies-literature | 2021 Apr-Jun

REPOSITORIES: biostudies-literature