Body size and composition and risk of site-specific cancers in the UK Biobank and large international consortia: A mendelian randomisation study.

ABSTRACT:

Background

Evidence for the impact of body size and composition on cancer risk is limited. This mendelian randomisation (MR) study investigates evidence supporting causal relationships of body mass index (BMI), fat mass index (FMI), fat-free mass index (FFMI), and height with cancer risk.

Methods and findings

Single nucleotide polymorphisms (SNPs) were used as instrumental variables for BMI (312 SNPs), FMI (577 SNPs), FFMI (577 SNPs), and height (293 SNPs). Associations of the genetic variants with 22 site-specific cancers and overall cancer were estimated in 367,561 individuals from the UK Biobank (UKBB) and with lung, breast, ovarian, uterine, and prostate cancer in large international consortia. In the UKBB, genetically predicted BMI was positively associated with overall

SUBMITTER: Vithayathil M 

PROVIDER: S-EPMC8320991 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature