Magnetic resonance radiomics features and prognosticators in different molecular subtypes of pediatric Medulloblastoma.

ABSTRACT:

Purpose

Medulloblastoma (MB) is a highly malignant pediatric brain tumor. In the latest classification, medulloblastoma is divided into four distinct groups: wingless (WNT), sonic hedgehog (SHH), Group 3, and Group 4. We analyzed the magnetic resonance imaging radiomics features to find the imaging surrogates of the 4 molecular subgroups of MB.

Material and methods

Frozen tissue, imaging data, and clinical data of 38 patients with medulloblastoma were included from Taipei Medical University Hospital and Taipei Veterans General Hospital. Molecular clustering was performed based on the gene expression level of 22 subgroup-specific signature genes. A total 253 magnetic resonance imaging radiomic features were generated from each subject for comparison between different molecula

SUBMITTER: Chang FC 

PROVIDER: S-EPMC8321137 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature