BinomiRare: A robust test for association of a rare genetic variant with a binary outcome for mixed models and any case-control proportion.

ABSTRACT: Whole-genome sequencing (WGS) and whole-exome sequencing studies have become increasingly available and are being used to identify rare genetic variants associated with health and disease outcomes. Investigators routinely use mixed models to account for genetic relatedness or other clustering variables (e.g., family or household) when testing genetic associations. However, no existing tests of the association of a rare variant with a binary outcome in the presence of correlated data control the type 1 error where there are (1) few individuals harboring the rare allele, (2) a small proportion of cases relative to controls, and (3) covariates to adjust for. Here, we address all three issues in developing a framework for testing rare variant association with a binary trait in individuals harb

SUBMITTER: Sofer T 

PROVIDER: S-EPMC8321319 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature