Canonical features of human antibodies recognizing the influenza hemagglutinin trimer interface.

ABSTRACT: Broadly reactive antibodies targeting the influenza A virus hemagglutinin (HA) head domain are thought to be rare and to require extensive somatic mutations or unusual structural features to achieve breadth against divergent HA subtypes. Here we describe common genetic and structural features of protective human antibodies from several individuals recognizing the trimer interface (TI) of the influenza A HA head, a recently identified site of vulnerability. We examined the sequence of TI-reactive antibodies, determined crystal structures for TI antibody-antigen complexes, and analyzed the contact residues of the antibodies on HA to discover common genetic and structural features of TI antibodies. Our data reveal that many TI antibodies are encoded by a light chain variable gene segment inco

SUBMITTER: Zost SJ 

PROVIDER: S-EPMC8321569 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature