Essential shared and species-specific features of mammalian oocyte maturation-associated transcriptome changes impacting oocyte physiology.

ABSTRACT: Oogenesis is a complex process resulting in the production of a truly remarkable cell-the oocyte. Oocytes execute many unique processes and functions such as meiotic segregation of maternal genetic material, and essential life-generating functions after fertilization including posttranscriptional support of essential homeostatic and metabolic processes, and activation and reprogramming of the embryonic genome. An essential goal for understanding female fertility and infertility in mammals is to discover critical features driving the production of quality oocytes, particularly the complex regulation of oocyte maternal mRNAs. We report here the first in-depth meta-analysis of oocyte maturation-associated transcriptome changes, using eight datasets encompassing 94 RNAseq libraries for human,

SUBMITTER: Schall PZ 

PROVIDER: S-EPMC8321790 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature