On the potential role of globins in brown adipose tissue: a novel conceptual model and studies in myoglobin knockout mice.

ABSTRACT: Myoglobin (Mb) regulates O₂ bioavailability in muscle and heart as the partial pressure of O₂ (Po₂) drops with increased tissue workload. Globin proteins also modulate cellular NO pools, "scavenging" NO at higher Po₂ and converting NO₂^- to NO as Po₂ falls. Myoglobin binding of fatty acids may also signal a role in fat metabolism. Interestingly, Mb is expressed in brown adipose tissue (BAT), but its function is unknown. Herein, we present a new conceptual model that proposes links between BAT thermogenic activation, concurrently reduced Po₂, and NO pools regulated by deoxy/oxy-globin toggling and xanthine oxidoreductase (XOR). We describe the effect of Mb knockout (Mb^-/-) on BAT phenoty

SUBMITTER: Blackburn ML 

PROVIDER: S-EPMC8321818 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature