Adipose tissue macrophage populations and inflammation are associated with systemic inflammation and insulin resistance in obesity.

ABSTRACT: Obesity is accompanied by numerous systemic and tissue-specific derangements, including systemic inflammation, insulin resistance, and mitochondrial abnormalities in skeletal muscle. Despite growing recognition that adipose tissue dysfunction plays a role in obesity-related disorders, the relationship between adipose tissue inflammation and other pathological features of obesity is not well-understood. We assessed macrophage populations and measured the expression of inflammatory cytokines in abdominal adipose tissue biopsies in 39 nondiabetic adults across a range of body mass indexes (BMI 20.5-45.8 kg/m²). Skeletal muscle biopsies were used to evaluate mitochondrial respiratory capacity, ATP production capacity, coupling, and reactive oxygen species production. Insulin sensiti

SUBMITTER: Kunz HE 

PROVIDER: S-EPMC8321823 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature